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Furthermore, deregulation of endogenous DA synthesis, storage, transportation and metabolism by pharmacological and genetic approaches can lead to deleterious effects on dopaminergic neurons

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Tumor cells respond to oxidative stress by altering the activity of antioxidant transcription factors, including HIF-1, essential for cellular redox homeostasis [72, 75]

All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA)

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Rotation of injection sites prevents lipodystrophy from repeated injections in the same location