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Some antihyperglycemic agents used to treat T2D, such as insulin, sulfonylureas and thiazolidinediones, can lead to weight gain and frequent episodes of hypoglycemia, which are associated with reduced quality of life and increased cardiovascular events

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This means your resting metabolic rate may gradually decline while on the medication, making post-discontinuation caloric balance harder without conscious dietary adjustment

The best option may vary based on a persons medical history and overall condition