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10.2310/7750.2014.14076 216 ZhangB.WangJ.ZhaoG.LinM.LangY.ZhangD.et al (2020)

If leg cramps become a persistent problem, a healthcare provider may recommend adjusting the dose of semaglutide or exploring other ways to manage this side effect

You should also learn what evidence connects this very rare side effect of semaglutide to the drug

Molecular Profile Peptide: Semaglutide Type: GLP-1 Receptor Agonist Sequence Length: 31 amino acids (synthetic analogue with modifications) Form: Lyophilized powder Purity: 98% (HPLC tested) Semaglutide includes proprietary fatty-acid and amino-acid modifications to extend half-life and is not typically displayed as a full open-source sequence by peptide suppliers

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Deborah Horn, a weight-loss expert with UTHealth Houston