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Lim SW, Jin L, Luo K, Jin J, Shin YJ, Hong SY, Yang CW (2017) Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress

It has not yet received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and therefore remains unavailable as a licensed treatment in the UK at this time

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Both treatments were found to be effective, with TTO demonstrating greater efficacy [333]

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