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Prescription weight loss drugs such as phentermine and topiramate (Qsymia) or bupropion and naltrexone (Contrave) are used for chronic, long-term weight loss, but only if adequate results occur

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Oral bioavailability ranges from 1030% due to first-pass hepatic metabolism and gastric degradation, while subcutaneous injection achieves near-100% bioavailability with direct systemic distribution

10.1371/journal.pbio.2006203 49 GalluzziL.VitaleI.AaronsonS

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Exercise regularly and/or throughout the day: Get in the habit of exercising most days through an activity that you enjoy, whether thats a morning walk around the neighborhood, a lunch break jog, or weight lifting before dinner