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October 29, 2022

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Supporting the idea that biguanides acted by increasing cellular AMP:ATP/ADP:ATP ratios, AMPK was not activated by either metformin or phenformin in cells expressing an AMPK mutant that is insensitive to changes in AMP or ADP [17]

The interest in using Metformin for weight loss stems from personal experiences and limited clinical studies suggesting that it may help reduce appetite and improve insulin sensitivity, both of which could contribute to weight loss in some individuals