Effects in active malignancy are not well characterized, and most clinicians treat this as an exclusion until more data exists
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"Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice." Biochemical Pharmacology
Injected testosterone shuts the testes down, because the brain sees enough hormone and stops sending its own signal
Taking too much can make side effects, like feeling or being sick, diarrhoea, or headaches, worse and increase the chance of dehydration
It sits with those who can process, move, and deliver in time