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Unfortunately, these anti-IGF-1R agents have very limited efficacy in clinical trials, 7,8,9 suggesting the existence of a mechanism to antagonize the IGF-1R inhibition in cancer cells

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PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)

It is also found in fruits, vegetables and meats

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When incorporated into scaffold matrices and hydrogel formulations, thymosin beta-4 has been shown to support endothelial and epicardial cell proliferation, enhance blood vessel formation, and promote myocardial tissue repair in post-ischemic models