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Critical clinical trial outcomes and ongoing registered trials are summarized in Tables 1 and 2, respectively
Innovent Biologics attached a fatty acid side chain to mazdutide to extend its half-life, allowing once-weekly dosing
The long-term safety data for tirzepatide continues to accumulate
21,24,25 In some instances, patients may remain on the lowest effective dose and only escalate as needed, such as when weight reduction plateaus
An average of 85 pounds lost over two years
Through this mechanism, GLP-1RAs may reduce endothelial dysfunction and oxidative stress, both of which are key contributors to sepsis pathophysiology (57)
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