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The research above (Badenhorst, Finkley, Abdulghani, Carey/Pickart) all studied topical application

(2005) Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium

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Beyond the toxic gain-of-function effects of mHTT, HD pathogenesis involves a range of interconnected mechanisms, including mitochondrial dysfunction, transcriptional dysregulation, impaired autophagy, proteostasis failure, excitotoxicity, oxidative stress, and chronic neuroinflammation [3843]