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Visible improvement normally happens within 48 weeks of regular use

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10.1126/sciadv.abn6027 75 JiangT.ChengH.SuJ.WangX.WangQ.ChuJ.et al (2020)

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BioFactors 6:321338 Suh JH, Wang H, Liu RM, Liu J, Hagen TM (2004) (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis