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Ginger is known to cause heartburn in some people

Unrepaired 8-oxo-G is potentially one of the most mutagenic lesions, since it pairs with A, inducing G T transversions 40 , and represents a prominent candidate to be a marker of ROS-induced mutagenesis and tumorigenesis 41

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Patients may experience more pronounced gastrointestinal symptoms during titration, which can influence their willingness to continue treatment

However, each approach offers unique benefits and drawbacks

The contraindication and dose-frequency limit are precautionary based on the BP signal, not based on a serious cardiovascular event rate in trials