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In two small trials ( n = 20 and n = 32), 1500 mg/day of metformin for 3 months improved BMI, testosterone, leptin, and lipids, but had no effects on androgens, insulin resistance, or ovulation or pregnancy rates compared with placebo

The FDA approval of the first oral GLP-1 medication for obesity in December 2025 represents a major milestone in weight loss treatment options

Oxidative stress has been identified as having an important role in cerebrovascular disease and given increasing recognition of the overlap between vascular dementia and AD (mixed dementia) and the contribution of vascular changes to AD [93] investigating potential effects of cerebrovascular disease as a covariate would be an important direction for future studies

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doi: 10.1111/dom.13331