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Compared to MOTS-c, which targets mitochondrial energy metabolism through a completely separate cellular mechanism and requires only 4 injections per cycle, Epithalon runs for 10 consecutive nightly doses and focuses on cellular renewal and the aging process itself

Following the experiment, the animal should be moved to a previously prepared breeding cage

Furthermore, glucagon stimulates lipolysis by activating hormone-sensitive lipase in the adipocytes and inhibiting lipogenesis

Analysis of pooled data To increase the sample size and BW range, five independent experiments totalling 145 rats were pooled into vehicle (V, n = 38), drug (CS + C + S, n = 57) and calorie restriction (WM + PF, n = 50) groups (Extended Data Table 1)

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