hengrui glp-1 China Medicine has registered a Phase III, multicenter, randomized, double-blind clinical trial of the GLP-1R/GIPR dual agonist HRS9531 for the treatment of obesity (NCT06396429; HRS9531-301) AZ's China deals, Kailera-Hengrui—Fierce Pharma

[2] The takeaway for anyone interested in gut health is simple but powerful: because L-cells respond to signals arriving from the gut lumen, the environment inside your intestine including the composition and activity of your microbiome is directly upstream of how much GLP-1 gets made

You need to rotate between more locations to avoid tissue irritation

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Miguens-Gomez et al 2021)

They typically contain prebiotic fiber (resistant starch, Fibersol), probiotics ( Akkermansia muciniphila , Bifidobacterium strains), or metabolic compounds (berberine, chromium picolinate, 5-HTP, saffron extract)

In the SURMOUNT-1 trial, tirzepatide produced average weight reductions of 15.0%, 19.5%, and 20.9% at studied doses compared with 3.1% with placebo over 72 weeks