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AOD9604 and Energy Balance Research In obese ob/ob and lean C57BL/6J mice treated for 14 days via mini-osmotic pumps, AOD9604 significantly reduced body weight gain in obese mice, associated with increased in vivo fat oxidation and increased plasma glycerol levels as an index of enhanced lipolysis without the hyperglycaemia or reduced insulin secretion associated with intact hGH treatment

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By dampening reward-driven behaviors, GLP-1 agonists could potentially reduce cravings and compulsive substance use

Its well-established role in cellular bioenergetics has made it a valuable research compound across multiple scientific disciplines

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[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Zhang Q., Li Q., Liu S., Zheng H., Ji L., Yi N., Bao W., Zhu X., Sun W., Liu X., et al