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The risk is much higher in men and women with gonadal dysgenesis, specially forms that arise from early gonadal differentiation defects, such as mutations in SRY and WT1, than in individuals with ovotesticular DSD or with hormone synthesis or action disorders (for example, androgen insensitivity) [168,169,170]

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Research suggests possible reductions in inflammatory markers and musculoskeletal pain encounters, but tirzepatide has not been established as an arthritis or joint-pain treatment

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