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Nature 589 , 246250 (2021)

It is also used with caution in breastfeeding women and children & adolescents (aged below 18 years)

In one study, participants taking 20mg of PQQ daily reported improvements in sleep duration, sleep quality, and the time it took to fall asleep after eight weeks

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The absolute risk increase for diabetic retinopathy complications was greater among patients with a history of diabetic retinopathy at baseline (semaglutide 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide 0.7%, placebo 0.4%)