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doi: 10.3389/fonc.2026.1680441 Received 06 August 2025 Revised 20 January 2026 Accepted 20 January 2026 Published 03 February 2026 Volume 16 - 2026 Edited by Arumugam Jayakumar, University of Texas MD Anderson Cancer Center, United States Reviewed by Enrico Martin, University Medical Center Utrecht, Netherlands Fei Song, Affiliated Hospital of Nantong University, China Updates Copyright 2026 Zhu, Shen, Yang, Han, Li, Xie, Tan, Lu, Ji and Zhang

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Specifically, MYC upregulates the glutamine transporter and induces the expression of GLS at both mRNA and protein levels [84, 85]

In both cell lines, the disulfide-bridged complex bound to the cells at levels comparable to the parental antibody (Fig

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