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These chondrocytes displayed a telomere erosion in the range of 900 bp, which was comparable with 30 years of native aging ( The detrimental influence of senescence has been previously demonstrated

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This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]

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High concentrations of iron can cause liver damage and organ failure