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For instance, NLY01, a long-acting PEGylated GLP-1RA with an extended half-life [41], effectively mitigates retinal ganglion cell (RGC) apoptosis induced by elevated intraocular pressure, a process mediated by a well-defined inflammatory cascade [44]

Archived from the original on August 28, 2011

In addition, clinical evidence suggests the drugs elevate the risk of pancreatitis, pancreatic cancer and gallbladder problems and adversely affect the bile ducts in the liver

However, it is surrounded by controversies, including off-label cosmetic use, supply shortages, and high costs

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