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Tumors in this subtype are usually resistant to endocrine therapy alone and only benefit when given additional treatments like chemotherapy or targeted therapy (97)

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Appetite suppressionwhile therapeutically desiredcan occasionally lead to undereating or nutritional gaps if protein and micronutrient intake aren't prioritized

DSIP and hypothalamic-pituitary modulation studies

Pharmacological or genetic glutaminase regulation along with oxidative chemotherapy can help to improve the design of combination strategies that escalate the rate of therapeutic success in cancer patients