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In a diabetes MRI substudy, liver fat fell up to 47% at 15 mg versus about 11% on insulin. In biopsy-confirmed fatty-liver disease with fibrosis, a large share of participants on 15 mg had disease resolution versus a small share on placebo. These are not microdose data

Lastly, taking supplemental doses of B12 higher than 100-150% of the RDA can trigger breakouts in acne-prone people.

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2021;137(6):e128-e144

Standard physicals check a narrow set of markers and screen for disease.A comprehensive assessment looks deeper, earlier, and wider

This is usually an indication that you have a methylation defect and need to slow down on the amount of B12 you are taking