In vivo studies in mice with acute and longterm hyperuricemia induced by potassium oxonate/hypoxanthine, the compounds exhibited significant hypouricemic potencies, which were slightly weaker and similar to febuxostat, at a dosage of 5 mg
By day three, most of the visible reaction has resolved
Inclusion and ethics statement The study presented here, has been approved and annually reviewed by the ethics board of the Ministry of Health of the Democratic Republic of the Congo (DRC) and the IRB board of the Oregon Health and Sciences University
The treatment is generally well-tolerated, with manageable side effects, and is administered via once-weekly subcutaneous injections, promoting patient adherence and consistent usage
These are rare but can include mild discomfort at the injection site
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