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Patients taking tirzepatide in both trials had a 1617% reduction in body weight, along with improvements in OSA-specific hypoxic burden, and high sensitivity C-reactive protein (a biomarker of systemic inflammation and cardiovascular risk) [113, 114]

The efficacy of the approach is demonstrated with three GLP-1-oligourea hybrids showing prolonged activity in vivo

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doi: 10.1016/j.abb.2012.02.016

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6), suggesting that GSH was not converted to Glu for activation of systemic Ca 2+ signaling