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Long-term considerations: Understanding potential long-term effects, both positive and negative, informs research decisions

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This elevation was generally observed early in treatment and appeared to plateau over time rather than continuing to rise progressively, though this observation should be regarded as exploratory given the trial design

The contrary view: weight loss is not always durable The BP improvements described above assume sustained weight loss

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Participants who had not lost at least 5% of their starting body weight by week 12 rarely achieved robust results by week 48