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Uricases are employed in the treatment of refractory gout and are capable of achieving a rapid reduction in hyperuricemia, significant resolution of tophi, alleviation of chronic joint pain, and enhancement of overall quality of life

Understanding why the evidence for DSIP is weak, and being able to say so plainly, is itself a clinical skill

Long-term treatment with inclisiran has validated the safety and effectiveness of siRNA therapy for dyslipidemia, 407 significantly advancing drug development at the RNA level

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