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Hoover published in 1941, were the action of pepsin on native and urea-denatured proteins were compared (Lineweaver and Hoover, 1941)

doi: 10.3390/toxins13020147

Human trials need to define the product, route, dose, comparator, outcomes, adverse-event collection, and follow-up before those claims can be tested reliably

Management should be individualized based on risk factors for delayed gastric emptying, with strategies such as a 24-hour liquid diet before surgery for higher-risk patients rather than a blanket recommendation to discontinue the medication