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In the U.S, the incidence is approximately 1: 142,000 based on newborn screening data.[10] In Japan, the incidence is approximately 1 in 40,000.[11] The Faroe Islands, an archipelago in the North Atlantic, report the highest incidence of PCD, which is 1 in 300.[12] Some patients with PCD have no or minimal symptoms, and this milder phenotype may remain undiagnosed throughout their entire life

Zhang et al., 2011

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Underlying causes of these GI symptoms appear varied

When lifestyle stress or poor diet weakens GLP-1, losing weight feels harder than it should