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The accumulation of senescent cells in different organs is a precursor of fibrosis development, neurological disorders, or chronic diseases and the rational to develop specific therapies targeting senescent cells has emerged as a promising therapeutic way 2,3,4

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178,179 Additionally, cAMP can activate Rap1 through EPAC (Exchange Protein directly Activated by cAMP), 180,181,182 which is involved in regulating insulin secretion

& Dziadek, J