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Homocysteine accumulates in the blood, causing vascular damage and micro-clotting, while downstream glutathione synthesis grinds to a halt

Given a drugs elimination clearance, calculate the maintenance dose needed to achieve or maintain an average steady-state drug level (Css) using either a continuous infusion (mg/hr) or dose per time interval (e.g

doi: 10.1021/acs.jmedchem.5b00726 23 FrasJPDaviesMJRosenstockJManghiFCPLandLFBergmanBet al