The synthesis of endogenous glutathione occurs in a tightly regulated, two-step enzymatic process
May be associated with periductular fibrosis and periductular cell infiltration
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However, free iron in mitochondria and the cytoplasm can generate highly oxidative HO, which damages polyunsaturated fatty acids (PUFAs) in the phospholipid bilayer, leading to mitochondrial outer membrane permeabilization (MOMP), ultimately abrogating DNA stability and inducing cell death
Shan Xiang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers