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Uribe P, Andrade L, Gonzalez S

En este artculo explicamos qu es y por qu no debe interpretarse como una solucin sencilla, rpida o aislada para tratar la obesidad

For example, individuals receiving placebo may not experience satisfactory weight loss and as a result may adopt another behavioral measure or weight-loss medication (other than the active medication) during the trial, and thus experience a larger reduction in body weight than if they had only received placebo

This provides biological plausibility for some observed effects, though mechanisms remain an area of ongoing investigation

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Whilst some probiotic strains may theoretically influence endogenous GLP-1 secretion through metabolite production, there is no established evidence that supplements achieve clinically meaningful increases in circulating GLP-1 levels