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For advanced protocols requiring 150200 mg daily, doses above 1.0 mL may be split into two injections at different sites to improve comfort

[PubMed] [Google Scholar] Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G, 2005

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When MC1R is activated, melanocytes increase eumelanin synthesis (the dark, protective pigment), producing a gradual tan without UV exposure or with reduced UV exposure needed to achieve the same tanning result

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