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Patients typically lost 18-20% of their body weight over one year 34 , helping reduce airway obstruction

The most commonly reported adverse events are gastrointestinal reactions, including nausea, vomiting, diarrhea, and constipation, which typically occur during the early phase of treatment and tend to diminish or resolve with continued therapy (55, 56)

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J Autoimmun 108:102402 Li L, Wang X, Sharvan R, Gao J, Qu S (2017) Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways