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A possible genotype-phenotype correlation has been proposed with homozygous carriers of frameshift variants affecting the MPTb domain displaying a more severe clinical course than that observed in individuals harboring single amino acid changes in the FADS domain that are potentially more responsive to riboflavin therapy [34]
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Moderate-to-severe pain should be managed with strong opioids (e.g
- V th chng ta cn phi b sung Glutathione hng ngy l cch duy nht gip bn c c hi chin u chng li cc yu t gy hi m hng ngy chng ta vn tip xc vi n
Similarly, Gopalan et al
[7] That high dose is reserved for special cases and always done under medical supervision (generally via slow IV infusion)
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