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Thermal injury of the rectum can be prevented by controlling the temperature of the coffee enema, and the risks of electrolyte imbalance or septicemia due to frequent enema are not relevant for patients undergoing a one-time procedure for small bowel preparation

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This demonstrated that the -MSH-MC1R signaling pathway induces melanin production predominantly by elevating intracellular cAMP levels, and the inhibition of which can exert inhibitory effects on melanogenesis

Borgese, N., Aggujaro, D., Carrera, P., Pietrini, G

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