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This risk is heightened by genetic variants such as the OATP1B1 R57Q polymorphism, which impairs drug transport and can lead to systemic toxicity (62, 63)

Nrf2 Activation as a Strategy for COVID-19 Treatment The involvement of Nrf2 signalling in coronavirus disease 19 (COVID-19) is sustained by the marked cytoprotective ability of Nrf-2 in responding to stressors and its potential role in the treatment of pathologies characterized by oxidative and/or inflammatory events

however, it was shown early in the pandemic that this exposure did not lead to preexisting antibodies that could cross-recognize SARS-CoV-2 in most individuals [71]

The available animal studies were not sufficient to resolve this concern because they did not provide a comprehensive dose-ranging, long-term carcinogenicity programme

doi: 10.1016/j.beem.2020.101388 2