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The cultural heritages mainly show the characteristic of changing from concentration in the Hehuang area to dispersion in the surrounding areas

Moreover, the high hydrophilicity of the linker was retained and was able to mitigate the aggregation potential of the ADC with other lipophilic payloads (the solubility of the pyrophosphate diester linker drug is greater than 5 mg/mL)

Chemically labile linkers are widely used in ADC clinical pipelines, with acid-sensitive linkers (such as hydrazones and silyl ethers) and disulfide linkers leading the field

2016 Sep Federico Cacciapuoti