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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

GLP mimetics are currently widely used in the treatment of Type 2 diabetes while both physiological and pathophysiological effects on the exocrine pancreas are less clear

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experimental studies with other GLP-1 analogues (exendin-4 and liraglutide) have shown evidence of inhibition of oxidative stress, decreased apoptosis and prevalence of injured cells, decreased vascular proliferation, and increased c AMP levels in neurons and anti-inflammatory activity in microglial cells [67]

Another meta-analysis showed that HbA1c was reduced 2.1% and body weight 8.6kg with 15mg dose