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Furthermore, researchers observed that when the anti-GIPR antibody was used in combination with a glucagon-like peptide-1 receptor agonist, the weight loss effects were enhanced in both DIO mice and non-human primates

[1] [3] Tirzepatide functions as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

These can be mild reactions or severe reactions, depending on the individual

No pharmacological overlap washout is needed because both drugs are GLP-1 agonists, though re-escalating through the full semaglutide dose ladder is recommended to minimize GI side effects

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Combination therapy with DPP-4 inhibitors and pioglitazone in type 2 diabetes: Theoretical consideration and therapeutic potential