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UV-B increases the expression of genes such as PAL, CHS, and RCD

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The prolonged GH elevation from DAC may increase the likelihood and duration of side effects such as water retention, joint discomfort, and potential IGF-1 overstimulation compared to pulsatile no-DAC protocols

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As more non-weight indications emerge, including potential applications for addiction, Alzheimer disease, fatty liver disease, and chronic kidney disease, the relevance of BMI as the primary gatekeeper will diminish