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It is unknown whether compounded tirzepatide causes thyroid C-cell tumors in humans

GE Port J Gastroenterol 22(6):268276

Further research is needed to understand whether this transition is driven by biochemical cues associated with localized hypoxia within the fibrotic regions, mechanical cues arising from local tissue stiffening, or a combination of both

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Retatrutide GI side effects tend to be more pronounced at equivalent efficacy levels, likely due to the additional glucagon-mediated GI motility effects layered on top of the GLP-1 gastric slowing

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