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The serum-induced increase in p53 ubiquitination was blocked by a PI3K inhibitor, suggesting that phosphorylated Akt enhances the ubiquitination-promoting function of MDM2, determining reduction of the p53 protein

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Hypertens Res 46 , 18921899 (2023)

For instance, one drug could interfere with the metabolism of another, leading to increased drug levels and potential toxicity, or decreased levels, leading to reduced efficacy

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Clinical and Scientific Updates for Molecular Subsets of Colorectal Cancer