soul trial oral semaglutide cardiovascular outcomes results 2024 2025 nejm Reduces CV Events in T2DM – (NEJM, Mar 2025) Relevant for: cardiology, diabetology, nephrology, internal medicine 🧪 T2DM + ASCVD/CKD 💊 Oral semaglutide 14 mg vs placebo 📉 Oral Semaglutide and Cardiovascular Outcomes

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aleniglipron does not T2D data : Orforglipron has ACHIEVE-3 head-to-head vs oral semaglutide Company backing : Eli Lilly (orforglipron) vs Structure Therapeutics (aleniglipron) Conclusion# The oral GLP-1 small molecule space is developing into a two-horse race between aleniglipron and orforglipron

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I conclude with a discussion of policy around bulk manufacturing of semaglutide and other drugs without an established product quality reference standard

It not only supports genomic stability but may also influence the expression of genes involved in cellular stress responses

R.Blasco ConesaM