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Solid-state structures, cellular assays and microsomal studies confirm that BCHep substitution mitigates reactive metabolite formation, validating aryl-fused BCHeps as true bioisosteric replacements for meta -substituted arenes and 2-naphthalenes

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The article says to contact a provider if leg cramps are severe, persistent, or accompanied by swelling, weakness, or dark urine, which it flags as possible signs of rhabdomyolysis or serious muscle injury