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This leaves no upside to trying GLP-1 patches, Dushay says

Rapid weight loss can also affect body composition and hormone levels, including estrogen, which plays an important role in maintaining vaginal health and supporting protective lactobacillus bacteria, says registered dietician Lenia Lopez

There is also substantial impact on overall lifespan with an estimated 520 years of life lost for individuals with a BMI 45 [9]

Pathophysiology of Facial Volume Loss with GLP-1 Medications The use of semaglutide and similar compounds leads to a reduction in overall body fat , including subcutaneous facial fat

Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism

So, there is the possibility that more rigid erections are being misinterpreted at longer penile length