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In clinical research, approximately 7% of participants taking Retatrutide reported some form of skin discomfort, compared to just 1% in the placebo group

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Diabetes Ther (2018) 9:123351

Constipation can still occur after three months, and its timeline is not as clearly described as the pattern for nausea, vomiting, and diarrhea

The studies found sleep apnea patients on tirzepatide who weren't using a CPAP machine had 25 fewer breathing interruptions per hour compared with five fewer breathing disruptions among those taking a placebo