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Dev Comp Immunol 39:3962 Acknowledgements The authors would like to acknowledge the support of the Biotechnology Lab., Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Egypt, where the laboratory investigations were carried out

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Furthermore, the incidence of grade 3 or higher TRAEs was 25.6% among those who received dato-DXd vs 42.1% in patients who received paclitaxel in TROPION-Lung01