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The expression of GLP-1 and/or GLP-1R was found in hypothalamic feeding centers (28, 29), hindbrain matrix (30), the lateral parabrachial nucleus of the posterior nucleus (31), and mesolimbic substrates (3234), etc

Splitting falls into that category

Spacing doses further apart, consuming electrolyte-enhanced fluids between meals, and eating five to six small portions daily instead of three meals often resolves protracted nausea

They're not harmful for most people, but they're also not magic

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